Episode 182 features five of this year's #21toWatch winners - and if you're in the startup ecosystem, this one's unmissable.

For those unfamiliar, for the last eight years #21toWatch has been high on the regions innovation showcase, and the numbers speak for themselves. Over eight cohorts, 168 companies have landed on the list and collectively raised a staggering £721 million. This year marks a particularly poignant milestone: its Faye's final year running the programme after creating it back in 2018. But we think you’ll agree, she's gone out with a bang.

In this episode we talk to five of the winning companies:

• Cyclana Bio is tackling drug discovery from first principles, focusing on the extracellular matrix (the "biological dark matter" comprising 90% of your tissue). Lea Wenger explains how their multidisciplinary approach spanning Cambridge and Manchester is already attracting serious attention, with £5 million raised so far.
• Obasense is developing ultra-sensitive gas sensors for indoor air quality monitoring -particularly timely given the UK's new mould regulations. Founder, Osarenkhoe Ogbeide, is also building African mythology comics on the side!
• Myonerv is creating wearable neurostimulators for stroke rehabilitation. Sam Kourali's personal story - inspired by his cousin's stroke - drives a compelling business model targeting the US market's $60 billion opportunity.
• NANOPLUME just announced £2.2 million in funding for their bio-based aerogel thermal insulation. Three times more insulating than conventional materials, 60% lighter, and fully circular. Co-founder Tara Love says they're eyeing product launch within 18 months.
• Polytecks is mapping bioelectricity through flexible electrode arrays - starting with veterinary cardiology (dog heart disease affects over 80% of dogs) before moving to human diagnostics. Ruben Ruiz-Mateos Serrano tells us more.

This episode captures something essential about where UK deep tech innovation is heading. These aren't incremental improvements - they're fundamental reimagining’s of how we solve problems in healthcare, climate tech, and industrial systems.

Subscribe now and join the conversation. Because the next unicorn might just be one of these five.

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