Majid Fotuhi joins host Saranya Ravindran to explore how nutrition influences brain ageing. From anti-inflammatory diets and omega-3s to insulin resistance and metabolic health, this episode unpacks how what we eat shapes cognition and long-term brain resilience.

Timestamps:

01:10 – Mediterranean Diet

02:58 – Reducing Alzheimer's risk

03:37 – Dietary changes

05:44 – Metabolic dysfunction

08:00 – Exercise and Sleep

In this rapid-fire episode, Majid Fotuhi answers key questions on brain ageing - from memory-boosting habits and diet to stress, neurogenesis, and Alzheimer's risk. Perfect for a quick, science-backed overview of how to protect your brain.

This content has been funded by AstraZeneca, and is intended for healthcare professionals.

The content in this podcast is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment, nor to promote any specific product or therapy.

The guests have been compensated by AstraZeneca for their participation. The views expressed are their own and do not necessarily reflect those of the AMJ or AstraZeneca. If you choose to act on information discussed here, you do so at your own discretion.

Description:

As homologous recombination deficiency (HRD) testing becomes increasingly embedded in ovarian cancer pathways, clinicians need clear, operational guidance. This episode brings together expert perspectives on selecting tests, understanding outputs, and integrating results into guideline-aligned care.

Learn:

· HRD basics in plain language: what you're measuring and why

· Test selection and reporting nuances that affect downstream decisions

· Workflow design across oncology, pathology, and genetics

· Applying results to maintenance strategies and patient conversations

Speakers:

1. Rebecca Arend, Associate Director for Clinical Research, UAB O'Neal Comprehensive Cancer Center; Endowed Professor of Gynecologic Oncology, University of Alabama, USA.

2. Thomas Krivak, Director, Division of Gynecologic Oncology; Chief Surgeon, West Penn Hospital, USA.

3. Bhavana Pothuri, Gynecologic Oncologist, NYU Langone Health; Associate Professor, Department of Obstetrics and Gynecology, NYU Grossman School of Medicine, USA.

Järvinen-Seppo discusses how translational research is advancing understanding of early allergic disease, from maternal antibodies to global collaborations shaping the future of prevention and care.

Timestamps:

00:57 – Research scope

03:49 – Maternal antibodies

07:34 – Integrating new evidence

09:17 – International coordination

10:37 – Emerging areas

This episode examines the spectrum of food allergy, from IgE-mediated disease to food protein induced enterocolitis syndrome and eosinophilic conditions, and explores how diet, skin barrier function, and the microbiome interact in early life.

Timestamps:

00:53 – Spectrum of allergic diseases

05:00 – Nutrition and immune activation

07:22 – Atopic dermatitis

08:55 – IgE-mediated food allergy

10:28 – Future management pathways

Kirsi Järvinen-Seppo explores how the infant immune system develops, highlighting the role of maternal environment, breast milk composition, and early-life exposures in shaping allergy risk.

Timestamps:

00:57 – Infant immune system

02:06 – Maternal lifestyle factors

06:10 – Breast milk composition

10:13 – ESCAPE study

13:25 – Early sensitisation pathways

16:58 – Early risk stratification