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This Week in Cardiology

This Week in Cardiology

By: Medscape
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This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.Copyright 2019, Medscape Hygiene & Healthy Living Physical Illness & Disease Science
Episodes
  • Apr 24 2026 This Week in Cardiology

    Apr 24 2026 This Week in Cardiology
    Apr 24 2026

    PCSK9 inhibitors in high-risk diabetes without ASCVD, the CAAN-AF trial, conduction system pacing vs biventricular pacing, PFA and stroke, and therapeutic fashion infects expert consensus are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I VESALIUS-CV

    • VESALIUS-CV Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
    • JAMA Substudy https://jamanetwork.com/journals/jama/fullarticle/2847162

    II How Best to Maximize CRT Benefit in Patients with AF

    • CAAN-AF Trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag206/8654625?searchresult=1
    • Role of AV Node Ablation: Meta-analysis of Observational Studies https://www.jacc.org/doi/10.1016/j.jacc.2011.10.891

    III Stroke Rates in PFA vs Thermal Ablation

    • Comparative Safety of RF versus PFA for AF in a High-Volume US Medical Center https://esc365.escardio.org/Ehra-congress/sessions/18281

    IV Five New CSP Studies Presented and Published

    • HeartSync-LBBP Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2845803
    • PhysioSync-HF Trial

    https://jamanetwork.com/journals/jamacardiology/fullarticle/2845802

    • LEFT-BUNDLE-CRT Trial https://doi.org/10.1093/eurheartj/ehag225
    • Long-Term Follow-up of His-Alternative I Trial https://www.jacc.org/doi/10.1016/j.jacep.2026.02.016
    • LECART Trial https://esc365.escardio.org/Ehra-congress/sessions/17140

    V New EP Training Document Published

    • Advanced Training Statement on Clinical Cardiac Electrophysiology https://www.jacc.org/doi/10.1016/j.jacc.2026.01.074

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net
    Show more Show less
    33 mins
  • Apr 17 2026 This Week in Cardiology

    Apr 17 2026 This Week in Cardiology
    Apr 17 2026

    SPIRIT-HF, another spironolactone trial in HFpEF; the ESSENCE imaging study of the drug olezarsen; the SirPAD trial in peripheral artery disease; and ultrasound-guided femoral venous access are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I ACC: SPIRIT-HF Trial

    • FINEARTS-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
    • TOPCAT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1313731
    • TOPCAT Americas Trial https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255

    II A New Class of Lipid Lowering Drug Has a Dubious Debut At ACC

    • ESSENCE-TIMI 73b Imaging Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080012
    • ESSENCE-TIMI 73b Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2507227
    • IMPROVE IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1410489

    III Drug-Coated Balloons Looked Quite Good in PAD interventions

    Sirolimus-Coated Balloon Reduces Amputation Risk in Peripheral Artery Disease

    https://www.medscape.com/viewarticle/sirolimus-coated-balloon-reduces-amputation-risk-peripheral-2026a1000a83

    • SirPAD trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600360

    IV Another Vascular Story from the European Heart Rhythm Association

    • ULYSSES Trial https://doi.org/10.1093/eurheartj/ehag291
    • ULTRA-FAST Trial https://doi.org/10.1093/europace/eux175

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net
    Show more Show less
    28 mins
  • Apr 10 2026 This Week in Cardiology

    Apr 10 2026 This Week in Cardiology
    Apr 10 2026

    Three imaging-guided PCI trials (two with surprising results), LDL targets, an oral PCSK9 inhibitor, and another beta-blocker withdrawal trial are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I IVUS-Guided PCI

    • OPTIMAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600440
    • IVUS-CHIP Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601521
    • ILUMIEN IV Trial https://www.nejm.org/doi/10.1056/NEJMoa2305861
    • DKCRUSH VIII Trial https://doi.org/10.1016/j.jacc.2026.01.081

    II Ez-PAVE Trial — Low vs Very Low LDL-targets

    Does Ez-PAVE Support 'Lower Is Better' for LDL-C? https://www.medscape.com/viewarticle/does-ez-pave-support-lower-better-ldl-c-2026a1000akx

    • Ez-PAVE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
    • 2026 ACC/AHA Lipid Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423

    III CORALreef AddOn

    • CORALreef AddOn Trial https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.03.036
    • This Week in Caardiology 2-6-26 https://www.medscape.com/viewarticle/1003240
    • CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002

    IV Another Post-MI Beta-blocker Withdrawal Study: SMART-DECISION

    • SMART-DECISION Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601005
    • ABYSS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net
    Show more Show less
    32 mins
All stars
Most relevant
Dr Mandrola delivers excellent updates on recent publications. The podcast is just the thing for a commute: not too superficial, not too detailed, and do a great job placing the new clinical advances in the context of contemporary practice.

recommend to colleagues

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As a former Cardiology PA now working on the academic side of medicine, I’ve been out of practice for several years. Preparing to teach a cardiology course at a new program, I started brushing up on material—and stumbled across Dr. Mandrola’s podcast. Wow. I wish I had known about this resource back when I was still practicing clinically.

In just a short time, I’ve learned what’s new since I left practice, and even picked up on things I probably should have known better back then. More importantly, I’ve gained an entirely new appreciation for how to critically review clinical trials and recognize bias.

What sets this podcast apart is Dr. Mandrola’s humility and honesty: his willingness to point out flaws in studies, to admit when he doesn’t know something, and to change his perspective when the evidence supports it. That kind of intellectual honesty builds trust, and it makes him feel less like a distant expert and more like a fellow learner walking through the field with you.

I’ve flown through the last two years of episodes in just a week, and I’m looking forward to being a dedicated listener moving forward. Thank you, Dr. Mandrola, for approaching cardiology not as a lecture, but as a thoughtful, ongoing conversation.

Honest, Insightful, and Incredibly Valuable

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I absolutely love listening to this podcast and feel I practice medicine very similarly. I love your critical review of studies as it brings these areas to light. I especially loved your comment at the end of this podcast discussing the reasoning to go into EP. I agree with your reasons, and consider them the same for most fields of medicine, especially any in cardiology, which I practice as a PA in and have for 14 years. Going into medicine just for the money should never be the reason as it will only lead to frustration and burnout. Thank you for your honest reviews and feedback each week.

EP is not about the money -love this statement

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Me gusta el escepticismo del Dr Mandrola. Habla de su objetividad y su compromiso con la ciencia bien hecha

Muy informativo

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