Tramadol, a drug with more than 16 million U.S. prescriptions last year, is often viewed as the "safer opioid." However, new evidence suggests that perception is not just flawed, but dangerous. Pharmacist, Dante DiMatteo (PharmD), looks at the risks, including cardiac events and seizures, why it's still used, and what non-opioid pain solutions actually help.

What's in the Bottle? New bone health products: Bone Base Essentials and Bone PRO Essentials! Pharmacist Joey DiMatteo (PharmD) takes us through what each product is specifically designed to do, who they're for, and how to use them. Whether you're trying to rebuild bone denisty or just keep the healthy bones you have, there's a lot more to bone health than calcium. Joey talks through bone resorption & remodeling, osteoclasts, osteoblasts, and why protein is probably more important than calcium.

We love questions! Comment below or email us: questions@askjoedimatteo.com

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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:27 - Show Intro
01:07 - Tramadol Troubles
01:48 - What is Tramadol?
03:47 - Who is taking Tramadol?
04:35 - Details of the study
06:18 - Perceived efficacy
11:57 - Cardiac risk
14:07 - Kidney function risk
15:23 - Should you ask your doctor about this?
18:00 - Bone health & bone health supplements
19:15 - How bone actually works
20:23 - Bone health hierarchy of importance
25:20 - Bone Base Essentials
29:42 - Bone Pro
32:14 - Who is this for?
33:13 - Medications for bone health
34:47 - What else can cause bone loss?
36:40 - Why is protein important for bone health?
39:19 - Hormones
44:57 - Other takeaways
46:23 - Show Outro

SHOW NOTES:
1) Tramadol for chronic pain (BMJ) - https://tinyurl.com/b2c5r43h
2) Lipid Replacement Therapy (NIH) - https://tinyurl.com/238rb7th
3) Phosphatidylcholine's functions (NIH) - https://tinyurl.com/ys86m7cn
4) Phospholipid ebb and flow (NIH) - https://tinyurl.com/mr2m8mhz
5) Activation of lipoprotein lipase (NIH) - https://tinyurl.com/5n754wpa
6) Uptake and metabolism of 3H-fatty acid labelled lecithin (NIH) - https://tinyurl.com/4jwfbxpm
7) Effect of a hypercholesterolaemic diet (NIH) - https://tinyurl.com/mry8uksm
8) Protective effect of polyunsaturated phosphatidylcholine - https://tinyurl.com/yc4wjh6f
9) Water permeability and mechanical strength of polyunsaturated lipid bilayers (NIH) - https://tinyurl.com/57ruszhz
10) Effect of polyunsaturated phosphatidylcholine on lipid structure (NIH) - https://tinyurl.com/3dbxbnwx
11) Lipid replacement/antioxidant therapy (NIH) - https://tinyurl.com/7xa8565h

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Are your antidepressants leaving you feeling physically drained? In this episode, Joey DiMatteo (PharmD) leads an evidence-based discussion on how SSRIs often cause hidden nutrient deficiencies that can hinder your mental health progress and reduce the effectiveness of the antidepressants. We break down the research and science behind drug-induced nutrient depletion, the specific vitamins you are likely missing, and the professional-grade solutions to restore your well-being.

Additionally, Joey & Dante DiMatteo (PharmD) discuss the groundbreaking shift in pediatric guidelines: why early peanut introduction is the key to ending the peanut allergy epidemic. These new guidelines have already caused a 43% drop in childhood peanut allergies! Get the clarity you need from trusted medical experts who work on the front lines of pharmacy every day.

We love questions! Comment below or email us: questions@askjoedimatteo.com

ALL PRODUCTS: https://www.AskJoeDimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:31 - Show Intro
01:11 - SSRIs and Nutrients
02:33 - How do SSRIs work?
04:03 - The link with methylation
05:52 - The link with CoQ10
06:52 - What else is critical to overall wellbeing?
10:21 - Other vitamins and minerals that help
12:15 - Which supplements to take while on SSRIs
13:44 - Other things to check
14:20 - Potential drug interactions
22:32 - Peanut Allergies have plummeted in children
24:03 - More details about the study
26:31 - What is the IgE?
28:54 - Why have peanut allergies reduced?
32:08 - What are the new suggestions for peanut allergies?
35:39 - Show Outro

SHOW NOTES:
1) Folate in Depression (NIH) - https://tinyurl.com/2ka38bfa
2) Genes and SSRI-Associated Sexual Dysfunction (NIH) - https://tinyurl.com/4wpru9m2
3) Therapy for SSRI-Resistant Major Depression (NIH) - https://tinyurl.com/2w4a96uw
4) L-methylfolate for Major Depression (BMJ) - https://tinyurl.com/2wasv3dx
5) Guidelines for Early Food Introduction and Allergy (AAP) - https://tinyurl.com/4suncxjc
6) Peanut Allergy Rates Dropped (Article) - https://tinyurl.com/ynct84vv

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

In this episode, we are diving into a topic that—quite literally—gets people's blood pumping! We are looking at the brand new, 2025 American Heart Association and American College of Cardiology Hypertension Guidelines (AKA The PREVENT Standard), and to help us decode this massive document, we've got Dante DiMatteo (PharmD) in the hot seat.

The medical community is calling this a "watershed moment." We're moving from just looking at a number on a cuff to understanding the whole system—heart, kidneys, and metabolism. So what changed? What does it mean for you and your health? Generation Health explains it all!

We love questions! Comment below or email us: questions@askjoedimatteo.com

ALL PRODUCTS: https://www.AskJoeDimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:24 - Show Intro
01:22 - New Blood Pressure Guidelines
02:43 - What has been updated?
04:59 - How is kidney function related to blood pressure?
06:44 - Mechanisms of blood pressure and cognitive decline
08:58 - What are healthy blood pressure readings?
10:08 - How is someone diagnosed for high BP?
15:22 - What has changed?
19:44 - Changes to pharmacology
25:04 - Other pharmacology changes
26:28 - Changes to lifestyle modifications
32:23 - Show Outro

SHOW NOTES:
1) 2025 Guideline For High Blood Pressure in Adults (JACC Journals) - https://tinyurl.com/2hudprv5
2) Updated Hypertension Guidelines (Pharmacy Times) - https://tinyurl.com/mrxn7tkt
3) About PREVENT Risk Calculator (AHA) - https://tinyurl.com/mspjtyh2
4) PREVENT Online Calculator (heart.org) - https://tinyurl.com/3f7wxz6r

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.