Tramadol, a drug with more than 16 million U.S. prescriptions last year, is often viewed as the "safer opioid." However, new evidence suggests that perception is not just flawed, but dangerous. Pharmacist, Dante DiMatteo (PharmD), looks at the risks, including cardiac events and seizures, why it's still used, and what non-opioid pain solutions actually help.

What's in the Bottle? New bone health products: Bone Base Essentials and Bone PRO Essentials! Pharmacist Joey DiMatteo (PharmD) takes us through what each product is specifically designed to do, who they're for, and how to use them. Whether you're trying to rebuild bone denisty or just keep the healthy bones you have, there's a lot more to bone health than calcium. Joey talks through bone resorption & remodeling, osteoclasts, osteoblasts, and why protein is probably more important than calcium.

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Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
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YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:27 - Show Intro
01:07 - Tramadol Troubles
01:48 - What is Tramadol?
03:47 - Who is taking Tramadol?
04:35 - Details of the study
06:18 - Perceived efficacy
11:57 - Cardiac risk
14:07 - Kidney function risk
15:23 - Should you ask your doctor about this?
18:00 - Bone health & bone health supplements
19:15 - How bone actually works
20:23 - Bone health hierarchy of importance
25:20 - Bone Base Essentials
29:42 - Bone Pro
32:14 - Who is this for?
33:13 - Medications for bone health
34:47 - What else can cause bone loss?
36:40 - Why is protein important for bone health?
39:19 - Hormones
44:57 - Other takeaways
46:23 - Show Outro

SHOW NOTES:
1) Tramadol for chronic pain (BMJ) - https://tinyurl.com/b2c5r43h
2) Lipid Replacement Therapy (NIH) - https://tinyurl.com/238rb7th
3) Phosphatidylcholine's functions (NIH) - https://tinyurl.com/ys86m7cn
4) Phospholipid ebb and flow (NIH) - https://tinyurl.com/mr2m8mhz
5) Activation of lipoprotein lipase (NIH) - https://tinyurl.com/5n754wpa
6) Uptake and metabolism of 3H-fatty acid labelled lecithin (NIH) - https://tinyurl.com/4jwfbxpm
7) Effect of a hypercholesterolaemic diet (NIH) - https://tinyurl.com/mry8uksm
8) Protective effect of polyunsaturated phosphatidylcholine - https://tinyurl.com/yc4wjh6f
9) Water permeability and mechanical strength of polyunsaturated lipid bilayers (NIH) - https://tinyurl.com/57ruszhz
10) Effect of polyunsaturated phosphatidylcholine on lipid structure (NIH) - https://tinyurl.com/3dbxbnwx
11) Lipid replacement/antioxidant therapy (NIH) - https://tinyurl.com/7xa8565h

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Are your antidepressants leaving you feeling physically drained? In this episode, Joey DiMatteo (PharmD) leads an evidence-based discussion on how SSRIs often cause hidden nutrient deficiencies that can hinder your mental health progress and reduce the effectiveness of the antidepressants. We break down the research and science behind drug-induced nutrient depletion, the specific vitamins you are likely missing, and the professional-grade solutions to restore your well-being.

Additionally, Joey & Dante DiMatteo (PharmD) discuss the groundbreaking shift in pediatric guidelines: why early peanut introduction is the key to ending the peanut allergy epidemic. These new guidelines have already caused a 43% drop in childhood peanut allergies! Get the clarity you need from trusted medical experts who work on the front lines of pharmacy every day.

We love questions! Comment below or email us: questions@askjoedimatteo.com

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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:31 - Show Intro
01:11 - SSRIs and Nutrients
02:33 - How do SSRIs work?
04:03 - The link with methylation
05:52 - The link with CoQ10
06:52 - What else is critical to overall wellbeing?
10:21 - Other vitamins and minerals that help
12:15 - Which supplements to take while on SSRIs
13:44 - Other things to check
14:20 - Potential drug interactions
22:32 - Peanut Allergies have plummeted in children
24:03 - More details about the study
26:31 - What is the IgE?
28:54 - Why have peanut allergies reduced?
32:08 - What are the new suggestions for peanut allergies?
35:39 - Show Outro

SHOW NOTES:
1) Folate in Depression (NIH) - https://tinyurl.com/2ka38bfa
2) Genes and SSRI-Associated Sexual Dysfunction (NIH) - https://tinyurl.com/4wpru9m2
3) Therapy for SSRI-Resistant Major Depression (NIH) - https://tinyurl.com/2w4a96uw
4) L-methylfolate for Major Depression (BMJ) - https://tinyurl.com/2wasv3dx
5) Guidelines for Early Food Introduction and Allergy (AAP) - https://tinyurl.com/4suncxjc
6) Peanut Allergy Rates Dropped (Article) - https://tinyurl.com/ynct84vv

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

In this episode, we are diving into a topic that—quite literally—gets people's blood pumping! We are looking at the brand new, 2025 American Heart Association and American College of Cardiology Hypertension Guidelines (AKA The PREVENT Standard), and to help us decode this massive document, we've got Dante DiMatteo (PharmD) in the hot seat.

The medical community is calling this a "watershed moment." We're moving from just looking at a number on a cuff to understanding the whole system—heart, kidneys, and metabolism. So what changed? What does it mean for you and your health? Generation Health explains it all!

We love questions! Comment below or email us: questions@askjoedimatteo.com

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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:24 - Show Intro
01:22 - New Blood Pressure Guidelines
02:43 - What has been updated?
04:59 - How is kidney function related to blood pressure?
06:44 - Mechanisms of blood pressure and cognitive decline
08:58 - What are healthy blood pressure readings?
10:08 - How is someone diagnosed for high BP?
15:22 - What has changed?
19:44 - Changes to pharmacology
25:04 - Other pharmacology changes
26:28 - Changes to lifestyle modifications
32:23 - Show Outro

SHOW NOTES:
1) 2025 Guideline For High Blood Pressure in Adults (JACC Journals) - https://tinyurl.com/2hudprv5
2) Updated Hypertension Guidelines (Pharmacy Times) - https://tinyurl.com/mrxn7tkt
3) About PREVENT Risk Calculator (AHA) - https://tinyurl.com/mspjtyh2
4) PREVENT Online Calculator (heart.org) - https://tinyurl.com/3f7wxz6r

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Lithium appears to contribute to cognitive preservation during aging and a new study looks at what happens to the brain when lithium is deficient, possibly leading to Alzheimer's disease. Better still, it looks like increasing the brain's lithium levels may actually reverse the effects. Lithium orotate is getting a glow-up and we're excited for it!

Also, the "magic pill" may finally be real. Wegovy, one of the popular new GLP-1 weight-loss medications is now available as a daily oral prescription! How does it differ from injections and how is dosing affected? Is it cheaper than the shots?

We love questions! Comment below or email us: questions@askjoedimatteo.com

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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:29 - Show Intro
01:38 - Study: Alzheimer's and Lithium Deficiency
02:52 - What is Lithium?
04:26 - What was studied?
06:47 - Details about the animal study
08:55 - How is lithium protecting the brain?
12:22 - Lithium in drinking water
13:28 - Takeaways
16:21 - Wegovy Pill
17:31 - Details of the Wegovy Pill
19:45 - Do you need to titrate up?
20:36 - If it's working, do you need to take more?
22:49 - What's the difference between the pill and injectable?
23:59 - Differences in cost
25:13 - Other points
27:43 - Dietary suggestions while on Wegovy
29:54 - Show outro

SHOW NOTES:
1) Lithium and Alzheimer's (Nature) - https://tinyurl.com/aywhpx2h
2) Lithium deficiency and onset of Alzheimers (NIH) - https://tinyurl.com/y2dxvmdf
3) New GLP-1 Pill Compared to Shot (Web MD) - https://tinyurl.com/mt2mvtpv
4) Wegovy Pill in High Demand (NBC News) - https://tinyurl.com/ktb84h54
5) Wegovy pill now available across America (PR Newswire) - https://tinyurl.com/2t6uda9w

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

At the top of the year, U.S. Department of Health and Human Services Secretary Robert F. Kennedy, Jr. and U.S. Department of Agriculture Secretary Brooke Rollins released the Dietary Guidelines for Americans, 2025–2030, the most significant reset of federal nutrition policy in decades. Emphasizing "real food," the food pyramid we grew up with has essentially been turned upside down. Dante DiMatteo (PharmD) breaks down the changes: What's good, what's bad and what families should take away from this messy government food fight.

We love questions! Comment below or email us: questions@askjoedimatteo.com

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Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:26 - Show Intro
01:15 - New dietary guidelines
02:41 - What does this update affect?
05:18 - Why is this a "hostile takeover?"
12:12 - Specifics of the new guidelines
12:23 - Changes to Protein
17:07 - Changes to Fat
20:57 - The paradox that's occurring
23:32 - What the guideline authors are focused on
28:29 - Biomarker-dependent decision making
35:48 - Carbohydrate/Insulin Model
41:10 - International Reaction to these changes
42:19 - Blue zones
44:30 - Takeaways
45:35 - Show Outro

SHOW NOTES:
1) Official Gov't Site - https://realfood.gov/
2) The Scientific Foundation for the Dietary Guidelines (CDN) - https://tinyurl.com/586crtx3
3) Anabolic Resistance of Muscle Protein Turnover (NIH) - https://tinyurl.com/mvxp9xy7
4) Moderating "the great debate" (NIH) - https://tinyurl.com/4dhtadtb
5) Carbohydrate-insulin model (Royal Society) - https://tinyurl.com/mwa6m7cf
6) Historic Reset of U.S. Nutrition Policy (USDA) - https://tinyurl.com/64wxzt8k

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

VO2 Max is having a moment. It seems every fitness influencer and longevity specialist has decided to focus on it as the key metric for determining your health. Is it important? Yes. But making that the key indicator of fitness is a trap.

Then, Dante fields a listener question: What do you do when red wine turns your face, well...bright red. How can you enjoy a glass while avoiding that awful face flush and the terrible feeling that comes along with it?

We love questions! Comment below or email us: questions@askjoedimatteo.com

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CONNECT:
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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:23 - Show Intro
01:22 - VO2 Max
03:52 - What is VO2 Max?
05:51 - Who is Steve Magnus?
09:56 - What does VO2 Max tell you?
10:46 - What should you look at instead of VO2 max?
11:39 - Running economy
13:10 - Lactate Threshold
16:00 - Does VO2 max really matter?
18:49 - Is Zone 2 cardio related to VO2 max?
25:33 - Viewer Question: Red Wine Flush
26:04 - Why does this happen?
27:19 - What are the chemical issues with alcohol?
32:47 - Is there a "trick" with red wine to avoid flush?
34:51 - What to do with the data
40:29 - Show Outro

SHOW NOTES:
1) VO2 Max & metabolic health (Study) - https://tinyurl.com/bdh2jh6u

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

What effect does your personality have on how you feel about exercise? Do traits like extroversion or openness impact what works best for you? A new study suggests it could be the key factor in why some workouts work for some people and not others!

Dante DiMatteo (PharmD) unpacks all the details of the study, and offers suggestions from the research of how we can use our personality to actually enjoy the exercise we all need!

We love questions! Comment below or email us: questions@askjoedimatteo.com

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CONNECT:
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Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:33 - Show Intro
01:23 - Exercise Personality
02:42 - What is the Big 5 Personality Test?
05:53 - The Study's Goals
09:57 - What were the results of the test?
12:14 - Personality and Enjoyment of exercise
20:08 - Personality and Program Adherence
23:36 - How do we turn this into useful data?
35:37 - Show Outro

SHOW NOTES:
1) Personality Predicts Exercise Intensities (Study) - https://tinyurl.com/3xcrazkf

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

Testosterone isn't just for men! We look at the effects testosterone has on everything from thyroid function, sexual dysfunction, and basic joy in life. We cover proper testing as well as the therapies, lifestyle changes, and supplements that can help boost low levels in women.

Next, Dante examines the popular paleo diet and research that looks at the effects evolution, ecology, and economy has on the human diet. Put simply: paleo isn't really paleo! So what did our ancestors actually eat?

We love questions! Comment below or email us: questions@askjoedimatteo.com

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CONNECT:
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Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:29 - Show Intro
01:06 - Women & Testosterone
01:58 - What does testosterone do in women?
02:56 - Hormone Testing
06:21 - Sex Hormone Binding Globulin (SHBG)
07:51 - Free T3
09:02 - Chronic Cortisol
10:25 - Symptoms of Low-T in women
14:49 - Ways to naturally increase free testosterone
18:32 - Takeaways
21:02 - Paleo Diet isn't Actually Paleo
22:39 - Question about fasting and paleo
23:56 - What is the Paleo Diet?
27:49 - What's the point?
31:15 - So what should you do?
38:01 - Our meat vs. the meat of our ancestors
39:56 - Dante's advice to his friend
46:09 - Takeaway
47:45 - Show Outro

SHOW NOTES:
1) Testosterone therapy in men with androgen deficiency (NIH) - https://tinyurl.com/2uy6phe8
2) Impact of oral contraceptives on globulin and androgen levels (NIH) - https://tinyurl.com/3ztvtj24
3) Zinc and Testosterone Levels (NIH) - https://tinyurl.com/ywhyz3d6
4) Vitamin D and Testosterone (NIH) - https://tinyurl.com/ynyb842d
5) Evolution of Human Diet (NIH) - https://tinyurl.com/2wcwhyf7

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.