Signal and Symptoms Podcast Podcast By Harvey Castro MD Junaid Kalia MD & Edward Marx cover art

Signal and Symptoms Podcast

Signal and Symptoms Podcast

By: Harvey Castro MD Junaid Kalia MD & Edward Marx
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Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions affect patient care, getting it right isn't optional.Copyright 2026 Harvey Castro MD, Junaid Kalia MD, & Edward Marx Hygiene & Healthy Living Physical Illness & Disease Politics & Government
Episodes
  • AI Is In Healthcare—So Why Isn't It Working?

    AI Is In Healthcare—So Why Isn't It Working?
    Mar 24 2026

    The overarching signal is: we're early, it's messy, and the people closest to the work know it best.

    In this episode, Dr. Andrew Kim joins hosts Dr. Junaid Kalia, Dr. Harvey Castro, and Eward Marx for an unfiltered look at what healthcare AI implementation looks like from the inside. They are diagnosing the vendor translation failures, the physician workflow wars, the governance structures being built in real time, and the looming AI-vs-AI battle between health systems and insurance companies.

    The episode reveals an insider implementer’s perspective on where most AI deployments succeed or fail. Tune in to reflect on where your organization sits on the healthcare AI adoption curve, and what role you play in closing the gap.

    What You Will Discover:

    - The AI Market Diagnosis

    - The Clinician Workflow-Vendor Roadmap Collision

    - AI Governance Inside a Health System

    - Forecast on AI Displacement

    - The “Magic Wand” Round

    - Personalization vs. McDonaldization in Medicine

    Referenced in the show:

    🖇️ "Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839542

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/



    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Andrew Kim, MD, MBA, Director of Physician Informatics, Baylor Scott & White Health

    💼LinkedIn - https://www.linkedin.com/in/andrew-kim-md-mba-65364a4/

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    20 mins
  • 71% of FDA-Approved AI May Be a Clinical Liability (Here’s Why)

    71% of FDA-Approved AI May Be a Clinical Liability (Here’s Why)
    Mar 17 2026
    When 71% of training data for FDA-approved AI comes from just three states, geographic bias shifts from a technical oversight to a direct clinical liability. To deliver on the promise of value-based care, we must move beyond "clean" academic datasets and integrate the diverse, real-world data that reflects the actual patients we serve.In this episode, Dr. Junaid Kalia and Dr. Harvey Castro sit down with Dr. Martin Willemink, a radiologist and former Stanford faculty member who transitioned into the entrepreneurial world to solve AI’s most significant bottleneck: data diversity. As a clinician-turned-founder of Segmed, Dr. Willemink provides a systematic look at why "garbage in, garbage out" is a systemic risk to patient safety and how building a more representative data pipeline is the only way to achieve true generalizability in healthcare AI. The conversation moves beyond the hype of algorithms to the "messy reality" of medicine. We explore the strategic shift from vision-only models to multimodal vision-language models (VLMs) and the emerging role of synthetic data in augmenting training sets where real-world data is scarce. What You Will Discover:- Intro: The Data Bottleneck of Healthcare AI- Dr. Willemink’s Journey- The Risk of Geographic Bias- Real-World Evidence vs. Academic Data- The Evolution of Multimodal AI- Ensuring AI Reliability across different Equipment Vendors - Navigating HIPAA compliance and "Expert Determination"- The Future of Synthetic Data- Strategic Implementation for Healthcare SystemsUltimately, solving the "data problem" is a prerequisite for clinical safety. By building representative pipelines that account for hardware heterogeneity and geographic diversity, we ensure that AI serves as a reliable extension of the clinician. This infrastructure is the only way to deliver accurate diagnostics and improved outcomes for every patient, ensuring that innovation translates into better care at the bedside rather than just a technical success in a silo.Referenced in the show:🖇️ "Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms" – https://pmc.ncbi.nlm.nih.gov/articles/PMC7509620/Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en 📑 Substack - https://harveycastromd.substack.com/ Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Martin Willemink, MD, PhD, FSCCT, Co-founder & Chief Scientific Officer at Segmed💼LinkedIn - http://linkedin.com/in/martin-willemink Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    21 mins
  • The Data Problem That Healthcare Can't Ignore

    The Data Problem That Healthcare Can't Ignore
    Mar 10 2026

    What happens when the data behind AI doesn't actually reflect the patients it's meant to help? And if precision medicine is the goal, what’s truly standing between us and getting there?

    These are not rhetorical questions. They sit at the center of this week's conversation with Dr. Saira Haque, Senior Director of Clinical Informatics at Pfizer Medical Affairs. Together with the hosts, they examine why AI's promise in healthcare keeps encountering the same recurring limitation: fragmented, unrepresentative data that was never built to reflect the full diversity of patients it is meant to serve.

    She argues that getting the data right is where the work begins. But data alone isn't enough. The human-in-the-loop is a non-negotiable. AI doesn't replace clinical judgment; it sharpens it.

    What You Will Discover:

    - Dr. Haque’s Career Journey

    - How She Views Healthcare AI

    - AI as the Latest in a Series of Tech Innovations

    - Keeping Up With the Pace of AI & Regulatory Change

    - AI Won't Replace You. Here's Why

    - Is AI-Developed Medicine Real? Rating the Hype

    - Global Regulatory Alignment on AI

    - Bias & Representational Gaps in Clinical AI Data

    - Synthetic vs. Augmented Data & Digital Twins

    - What Would Fix Healthcare AI Today?

    This episode doesn't offer a tidy roadmap. Yet, it offers something more enduring: a way of thinking about AI that is neither fearful nor naive.



    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Saira Haique, PhD, Lead, Advanced Medical Solutions Group

    💼LinkedIn - https://www.linkedin.com/in/saira-haque-phd-mhsa-famia-achip/


    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/
    Show more Show less
    21 mins
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