Episodes

  • AI Is In Healthcare—So Why Isn't It Working?

    AI Is In Healthcare—So Why Isn't It Working?
    Mar 24 2026

    The overarching signal is: we're early, it's messy, and the people closest to the work know it best.

    In this episode, Dr. Andrew Kim joins hosts Dr. Junaid Kalia, Dr. Harvey Castro, and Eward Marx for an unfiltered look at what healthcare AI implementation looks like from the inside. They are diagnosing the vendor translation failures, the physician workflow wars, the governance structures being built in real time, and the looming AI-vs-AI battle between health systems and insurance companies.

    The episode reveals an insider implementer’s perspective on where most AI deployments succeed or fail. Tune in to reflect on where your organization sits on the healthcare AI adoption curve, and what role you play in closing the gap.

    What You Will Discover:

    - The AI Market Diagnosis

    - The Clinician Workflow-Vendor Roadmap Collision

    - AI Governance Inside a Health System

    - Forecast on AI Displacement

    - The “Magic Wand” Round

    - Personalization vs. McDonaldization in Medicine

    Referenced in the show:

    🖇️ "Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839542

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/



    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Andrew Kim, MD, MBA, Director of Physician Informatics, Baylor Scott & White Health

    💼LinkedIn - https://www.linkedin.com/in/andrew-kim-md-mba-65364a4/

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    20 mins
  • 71% of FDA-Approved AI May Be a Clinical Liability (Here’s Why)

    71% of FDA-Approved AI May Be a Clinical Liability (Here’s Why)
    Mar 17 2026
    When 71% of training data for FDA-approved AI comes from just three states, geographic bias shifts from a technical oversight to a direct clinical liability. To deliver on the promise of value-based care, we must move beyond "clean" academic datasets and integrate the diverse, real-world data that reflects the actual patients we serve.In this episode, Dr. Junaid Kalia and Dr. Harvey Castro sit down with Dr. Martin Willemink, a radiologist and former Stanford faculty member who transitioned into the entrepreneurial world to solve AI’s most significant bottleneck: data diversity. As a clinician-turned-founder of Segmed, Dr. Willemink provides a systematic look at why "garbage in, garbage out" is a systemic risk to patient safety and how building a more representative data pipeline is the only way to achieve true generalizability in healthcare AI. The conversation moves beyond the hype of algorithms to the "messy reality" of medicine. We explore the strategic shift from vision-only models to multimodal vision-language models (VLMs) and the emerging role of synthetic data in augmenting training sets where real-world data is scarce. What You Will Discover:- Intro: The Data Bottleneck of Healthcare AI- Dr. Willemink’s Journey- The Risk of Geographic Bias- Real-World Evidence vs. Academic Data- The Evolution of Multimodal AI- Ensuring AI Reliability across different Equipment Vendors - Navigating HIPAA compliance and "Expert Determination"- The Future of Synthetic Data- Strategic Implementation for Healthcare SystemsUltimately, solving the "data problem" is a prerequisite for clinical safety. By building representative pipelines that account for hardware heterogeneity and geographic diversity, we ensure that AI serves as a reliable extension of the clinician. This infrastructure is the only way to deliver accurate diagnostics and improved outcomes for every patient, ensuring that innovation translates into better care at the bedside rather than just a technical success in a silo.Referenced in the show:🖇️ "Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms" – https://pmc.ncbi.nlm.nih.gov/articles/PMC7509620/Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en 📑 Substack - https://harveycastromd.substack.com/ Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Martin Willemink, MD, PhD, FSCCT, Co-founder & Chief Scientific Officer at Segmed💼LinkedIn - http://linkedin.com/in/martin-willemink Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    21 mins
  • The Data Problem That Healthcare Can't Ignore

    The Data Problem That Healthcare Can't Ignore
    Mar 10 2026

    What happens when the data behind AI doesn't actually reflect the patients it's meant to help? And if precision medicine is the goal, what’s truly standing between us and getting there?

    These are not rhetorical questions. They sit at the center of this week's conversation with Dr. Saira Haque, Senior Director of Clinical Informatics at Pfizer Medical Affairs. Together with the hosts, they examine why AI's promise in healthcare keeps encountering the same recurring limitation: fragmented, unrepresentative data that was never built to reflect the full diversity of patients it is meant to serve.

    She argues that getting the data right is where the work begins. But data alone isn't enough. The human-in-the-loop is a non-negotiable. AI doesn't replace clinical judgment; it sharpens it.

    What You Will Discover:

    - Dr. Haque’s Career Journey

    - How She Views Healthcare AI

    - AI as the Latest in a Series of Tech Innovations

    - Keeping Up With the Pace of AI & Regulatory Change

    - AI Won't Replace You. Here's Why

    - Is AI-Developed Medicine Real? Rating the Hype

    - Global Regulatory Alignment on AI

    - Bias & Representational Gaps in Clinical AI Data

    - Synthetic vs. Augmented Data & Digital Twins

    - What Would Fix Healthcare AI Today?

    This episode doesn't offer a tidy roadmap. Yet, it offers something more enduring: a way of thinking about AI that is neither fearful nor naive.



    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Saira Haique, PhD, Lead, Advanced Medical Solutions Group

    💼LinkedIn - https://www.linkedin.com/in/saira-haque-phd-mhsa-famia-achip/


    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/
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    21 mins
  • Why Healthcare Leaders Are Still Denying the AI Shift

    Why Healthcare Leaders Are Still Denying the AI Shift
    Mar 3 2026

    Global anxiety about AI and jobs is at its peak. And the data suggests people are right to feel it. But this episode isn't a warning. It's a diagnosis.

    Dr. Junaid Kalia, Edward Marx, and Dr. Harvey Castro step back from the weekly AI noise to examine the macro trajectory of the era we're actually living through — where five major innovation platforms are converging simultaneously, the cost of intelligence is collapsing, and the gap between technology and human adaptability has never been wider.

    The anxiety isn't irrational. It's a signal. And understanding what it's pointing to is the first step.

    What You'll Discover:

    - The Great Acceleration & The Five Converging Platforms

    - Why Brilliant People Are Still Dismissing AI — And What That Tells Us

    - The Cost of Intelligence Is Collapsing

    - AI in Healthcare: Real Gains, Real Barriers

    - The Human-in-the-Loop Design Challenge


    The future of healthcare isn't about choosing between human and machine—it's a collaboration where technology enhances our capabilities while human judgment and compassion remain at the forefront of patient care.


    Referenced in the show:

    🖇️ AI Healthcare Index by Dr. Harvey Castro – https://drive.google.com/file/d/18f04lD4nKtOmjJqc_J-F9bhbY4NkqZki/view?usp=sharing

    🖇️ Big Ideas Research Report by ARK Invest – https://www.ark-invest.com/big-ideas-2026


    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    20 mins
  • How a 200-Year-Old Hospital Is Adapting to an AI-Driven World

    How a 200-Year-Old Hospital Is Adapting to an AI-Driven World
    Feb 24 2026
    What happens when a 200-year-old safety-net hospital decides it's had enough of losing revenue to insurance denials and uses AI to fight back? The answer may change how you think about the intersection of clinical care and financial sustainability.In this episode, we sit down with Jani Rad, Dr. Kito Lord, and Robin Clanton from Regional One Health in Memphis, Tennessee. Together, they walk us through how a historically under-resourced hospital became an unlikely AI innovator — starting not with flashy technology, but with a simple question: can we just see our own data? From breaking down departmental silos to deploying AI that identifies payer denial patterns, generates appeals in bulk, and surfaces the big-picture revenue opportunities that encounter-by-encounter worklists will always miss — this team is actively building and testing a solution that directly bridges the gap between clinical documentation, finance, and patient outcomes.What You Will Discover:[00:00] Intro[00:52] Meet the Regional One Health Team[03:24] Data as the Starting Point[04:17] The Physician Advisor Program[06:00] First Tiptoe into AI[08:56] Seeing the Big Picture[10:00] From Data to Action[11:39] AI Checks and Balances[13:26] The AI Arms Race[14:28] Negotiating Denials at Scale[18:16] The Why Behind the WorkConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=enEdward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - https://www.marxadvisory.com/📹YouTube - https://www.youtube.com/@EdwardMarxSpecial Guest:Jani Rad, CEO, Regional One Health Solutions💼LinkedIn - https://www.linkedin.com/in/janirad/Kito Lord, MD, MBA, CHCQM-PHYADV💼LinkedIn - https://www.linkedin.com/in/kito-lord-md-mba-chcqm-phyadv-0b2a33a6/Learn more about Regional One Health🔗 https://www.regionalonehealth.org/Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    20 mins
  • Why Healthcare AI Startups Fail—Microsoft Global Health Leader Reveals the Fix

    Why Healthcare AI Startups Fail—Microsoft Global Health Leader Reveals the Fix
    Feb 17 2026
    Why do brilliant healthcare products fail before they ever reach patients? Sally Ann Frank, who leads Microsoft's worldwide strategy for health startups, exposes the fatal mistake and her proven protocol to avoid it.In this episode, Sally Ann Frank, Global Lead for Health & Life Sciences at Microsoft for startups, breaks down her proven Startup Protocol framework to achieve healthcare AI startup success in an agentic AI era. Drawing from her work with hundreds of early-stage companies, Sally emphasizes the critical mistake first-time founders make: investing all their energy in building a great product without doing customer discovery to prove anyone will actually pay for it. As AI agents transform healthcare delivery, she argues the conversation must shift from talking about AI capabilities to obsessively documenting the tangible value it creates—whether that's saving clinician time, improving patient outcomes, or streamlining administrative workflows.This episode provides Sally's tactical playbook for documenting value so convincingly that doing nothing becomes your customer's riskiest choice. From ideation to scale, her framework delivers the strategic clarity founders need to transform breakthrough ideas into fundable, sustainable businesses.What You Will Discover:- Sally Ann Frank: Her Mission In Action- Why Startups Fail Before Launch- How to Document End-User Value in Agentic AI era- Who Validates Value Before Scaling- The Unicorn Protocol- The No Free Pilots Rule- The Founder Mindset that Wins- Your Biggest Competitor: Customers Doing Nothing- A No Is Never Final Referenced in the show:🖇️ "The Start Up Protocol: A Guide for Digital Health Startups to Bypass Pitfalls and Adopt Strategies That Work" by Sally Ann Frank – https://www.amazon.com/Startup-Protocol-Startups-Pitfalls-Strategies/dp/103263944X/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1699382769&sr=8-8 🖇️ “The Unicorn Protocol: Digital Health Unicorns, How They Got There and What You Can Learn From Them” – https://www.amazon.com/Unicorn-Protocol-Digital-Health-Unicorns/dp/1032711019/?_encoding=UTF8&pd_rd_w=G2PgE&content-id=amzn1.sym.0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_p=0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_r=135-3915937-9293427&pd_rd_wg=HIDM6&pd_rd_r=dfd48b8a-14cb-42ef-98fc-b91d305d282c&ref_=aufs_ap_sc_dsk Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Sally Ann Frank, Global Lead for Health & Life Sciences at Microsoft for startups💼LinkedIn - https://www.linkedin.com/in/sallyafrank 🌐Website - https://www.sallyannfrank.com/ Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    20 mins
  • Why Only Doctors Can Fix What's Broken

    Why Only Doctors Can Fix What's Broken
    Feb 10 2026
    Healthcare is at a critical crossroads where clinicians are increasingly sidelined by administrative weight and third-party interests. The path forward isn't just surviving a broken system—it’s reclaiming our roles as primary stakeholders and system architects through a unified, "Doctor-to-Doctor" movement.Joining us to lead this conversation is Dr. Kianor Shah, a Southern California-based oral surgeon with 20 years of clinical experience and founder of the Global Summit Institute. Dr. Shah argues that the integration of medicine and dentistry is the next frontier of patient care, with AI serving as the "divine tool" to bridge these historical silos. By leveraging predictive analysis and peer-to-peer collaboration, we can move beyond the administrative burdens that cause burnout and return our focus to clinical excellence. This mission culminates in the 2026 Global Medical Dental AI Summit in London, a landmark effort to set rigorous, doctor-led standards for AI implementation. Together, we explore how transitioning from a service-provider mindset to a stakeholder mindset allows us to get around industry challenges and restore the oral-systemic health connection.What You Will Discover:- On Building the Doctor-to-Doctor movement- The Entrepreneurial Mindset- Bridging the Medical-Dental Gap- 2026 Global Medical Dental AI Summit- The Strategic Formula (0.5%) for Healthcare Transformation- Does a 3-5 Year Timeline Matter for Physician Leadership?- AI as the Unifying Catalyst, Not the End GoalAbout the Conference:2026 Global Medical Dental AI Summit📍 Leonardo Royale Hotel, London Tower Bridge📅 May 14-16, 2026🎤 100+ speakers | 3 tracks (Medical, Dental, Business) | 700 attendeesExclusive offer for Signals & Symptoms listeners:Use the discount code VIP20 for a special offer🔗 https://top100doc.com/london/ Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Kianor Shah DMD, MBS, Founder, Global Summits Institute💼LinkedIn - https://www.linkedin.com/in/kianorshah/ 🔗Website - https://kianorshah.com/ Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    18 mins
  • What FDA's Step Back Means in Building Credibility

    What FDA's Step Back Means in Building Credibility
    Feb 3 2026
    The FDA stepped back. Now, organizational governance is the only thing standing between innovation and liability.At CES 2026, the FDA officially announced it won't regulate wellness devices or Clinical Decision Support tools—removing approval bottlenecks and accelerating innovation. But this regulatory shift transfers responsibility to healthcare organizations themselves. Who builds the frameworks for data management when there's no FDA requirement? How do health systems justify physician time reviewing continuous patient streams without reimbursement pathways? And where does liability fall in this new landscape?In this episode, Dr. Junaid and Ed tackle the AI governance vacuum, exploring how healthcare AI agents can scale care, from filtering patient data to managing population health. They share J.P. Morgan Healthcare Conference updates on why organizational trust, rather than just regulatory stamps, is the key to successful AI in healthcare.What You Will Discover:- What changed in the regulatory landscape?- How the shift affects clinician workflows- Who should pay for clinical data platforms?- JPM Conference Insights- The importance of governance and trust- Biologics, biosimilars, and China competition- Practical strategies for continuous learningReferenced in the show:🖇️ "Supercharging a New FDA: Marty Makary on Science, Power & Patients" – https://www.youtube.com/watch?v=DBlOJpT9Y1Y 🖇️A Field Guide to Deploying AI Agents in Clinical Practice – https://mitsloan.mit.edu/shared/ods/documents?PublicationDocumentID=10789 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamd📑Substack - https://substack.com/@junaidkaliamd2025?Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=en📑Substack - https://harveycastromd.substack.com/ Edward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - https://www.marxadvisory.com/📹YouTube - https://www.youtube.com/@EdwardMarxVisit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    19 mins