Content warning: This conversation is about self-harm and suicide and may be distressing for some listeners. If you or someone you know is affected by these issues, please visit https://findahelpline.com/ a global database of support lines associated with the International Association for Suicide Prevention.

How effective are psychosocial interventions for self-harm and do they work differently for men and women? In this episode we discuss new evidence on sex differences in outcomes and the challenges of engaging men in mental health support. We also hear a lived experience perspective, offering insight into how support can be made more accessible and meaningful.

Click here to read the full article: https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(26)00018-9/fulltext

In this episode, Deputy Editor Ivana Nedic is joined by Dr Emiliano Calvo to discuss the rapidly evolving landscape of systemic cancer therapies. Ahead of the upcoming Series in The Lancet Regional Health – Europe, they explore its four key pillars: next-generation antibody-based therapies, antibody-drug conjugates, oncolytic viruses and cancer vaccines, and emerging cell therapies for solid tumours. The conversation examines the scientific advances driving these approaches, the challenges of toxicity management and equitable access across Europe, and how these innovative modalities may be sequenced and combined in the years ahead to reshape cancer care.

Join Senior Editor Stephanie Becker in an insightful conversation with Santiago Madero as they explore the evolving perspectives on psychedelic treatments, the latest developments in regulatory frameworks, and advances in psychedelic research.

This episode delves into the complex debates surrounding the therapeutic potential and experiential aspects of psychedelic treatments, highlighting the challenges and opportunities for their safe and effective implementation and regulation.

Click here to read the full article: https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(25)00329-1/fulltext